Category: Research Opportunity Program

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Jessica Xu’s Journey in ROP299

Hello everyone! My name is Jessica Xu, and I’ve just completed my second year in Biochemistry and Statistics at the University of Toronto. This past school year, I’ve had the wonderful opportunity to do a ROP299 project with Dr. Pascal Tyrrell and I’d like to share my experience with you all!

A bit about myself first: in high school, I was always interested in life sciences. My favourite courses were biology and chemistry, and I was certain that I would go to medical school and become a doctor. But when I took my first stats course in first year, I really enjoyed it and I started to become interested in the role of statistics in life sciences. Thus, at the end of my first year, while I was looking through the various ROP courses, I felt that Dr. Tyrrell’s lab was the perfect opportunity to explore my budding interest in this area. I was very fortunate to have an interview with Dr. Tyrrell, and even more fortunate to be offered a position in his lab!

Though it may be obvious, doing a research project when you have no research experience is very challenging! Coming into this lab having taken a statistics course and a few computer science courses in first year, I felt I had a pretty good amount of background knowledge. But as I joined my first lab meeting, I realized I couldn’t be more wrong! Almost every other word being said was a word I’d never heard of before! And so, I realized that there was a lot I needed to learn before I could even begin my project.

I then began on the journey of my project, which was looking at how two dimension reduction techniques, LASSO and SES, performed in an ill-posed problem. It was definitely no easy task! While I had learned a little bit about dimension reduction in my statistics class, I still had a lot to learn about the specific techniques, their applications in medical imaging, and ill-posed problems. I was also very inexperienced in coding, and had to learn a lot of R on my own, and become familiar with the different packages that I would have to use. It was a very tumultuous journey, and I spent a lot of time just trying to get my code to work. Luckily, with help from Amar, I was able to figure out some of the errors and issues I was facing in regards to the code.

I learned a lot about statistics and dimension reduction in this ROP, more than I have learned in any other courses! But most importantly, I had learned a lot about the scientific process and the experience of writing a research paper. If I can provide any advice based on my experience, it’s that sometimes it’s okay to feel lost! It’s not expected of you to have devised a perfect plan of execution for your research, especially when it’s your first time! There will be times that you’ll stray off course (as I often did), but the most valuable lesson that I learned in this ROP is how to get back on track. Sometimes you just need to take a step back, go back to the beginning and think about the purpose of your project and what it is you’re trying to tell people. But it’s not always as easy to realize this. Luckily Dr. Tyrrell has always been there to guide us throughout our projects and to make sure we stay on track by reminding us of the goal of our research. I’m incredibly grateful for all the support, guidance, and time that Dr. Tyrrell has given this past year. It has been an absolute pleasure of having the experience of working in this lab.

Now that I’ve taken my first step into the world of research, with all the new skills and lessons I’ve learned in my ROP, I look forward to all the opportunities and the journey ahead!

Jessica Xu

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Jacky Wang’s ROP399 Journey

My name is Jacky Wang, and I am just finishing my third year at the University of Toronto, pursuing a computer science specialist. Looking back on this challenging but incredible year, I was honoured to have the opportunity to work inside Dr. Tyrrell’s lab as part of the ROP399 course. I would love to share my experience studying and working inside the lab.

Looking back, I realize one of the most challenging tasks is getting onboard. I felt a little lost at first when surrounded by loads of new information and technologies that I had little experience with before. Though feeling excited by all the collision of ideas during each meeting, having too many choices sometimes could be overwhelming. Luckily after doing more literature review and with the help of the brilliant researchers in the lab (a big thank you to Mauro, Dimitri, and of course, Dr. Tyrrell), I start to get a better view of the trajectories of each potential project and further determine what to get out from this experience. I did not choose the machine learning projects, though they were looking shiny and promising as always (as a matter of fact, they turned out to be successful indeed). Instead, I was more leaning towards studying the sample size determination methodology, especially the concept of ill-posed problems, which often occur when the researchers make conclusions from models trained on limited samples. It had always been a mystery why I would get different and even contrasting results when replicating someone else’s work on smaller sample sizes. From there, I settled the research topic and moved onto the implementation details.

This year the ROP students are coming from statistics, computer science and biology etc. I am grateful that Dr. Tyrrell is willing to give anyone who has the determination to study in his lab a chance though they may have little research experience and come from various backgrounds. As someone who studies computer science with a limited statistics background, the real challenge lies in understanding all the statistical concepts and designing the experiments. We decided to apply various dimension reduction techniques to study the effect of different sample sizes with many features. I designed experiments around the principal component analysis (PCA) technique while another ROP student Jessica explored the lasso and SES model in the meantime. It was for sure a long and memorable experience with many debugging when implementing the code from scratch. But it was never more rewarding than seeing the successful completion of the code and the promising results.

I feel lucky and grateful that Dr. Tyrell helped me complete my first research project. He broke down the long and challenging research task into clear and achievable subgoals within our reach. After completing each subgoal, I could not even believe it sent us close to the finished line. It felt so different taking an ROP course than attending the regular lessons. For most university courses, most topics are already determined, and the materials are almost spoon-fed to you. But sometimes, I start to lose the excitement of learning new topics, as I am not driven by the curiosity nor the application needs but the pressure of being tested. However, taking the ROP course gives me almost complete control of my study. For ROP, I was the one who decides what topics to explore, how to design the experiment. I could immediately test my understanding and put everything I learned into real applications.

I am so proud of all the skills that I have picked up in the online lab during this unique but special ROP experience. I would like to thank Dr. Tyrrell for giving me this incredible study experience in his lab. There are so many resources out there to reach and so many excellent researchers to seek help from. I would also like to thank all members of the lab for patiently walking me through each challenge with their brilliant insights.

Jacky Wang

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Dianna McAllister’s ROP Adventures in the Tyrrell Lab!

My name is Dianna McAllister and I am approaching the finish of my second year at University of Toronto, pursuing a bioinformatics specialist and computer science major. This year I was given the incredible opportunity to work in Dr. Tyrrell’s lab for the ROP299 course.
I have just handed in my first ever formal research paper for my work in Dr. Tyrrell’s lab. My project observed the effectiveness of using grad-CAM visualizations on different layers in a convolutional neural network. Though the end results of my project were colourful heat maps placed on top of images, the process to get there was not nearly as colourful or as effortless as the results may seem. There was lots of self-teaching, debugging, decision-making and collaboration that went on behind the scenes that made this project difficult, but much more rewarding when complete.
My journey in Dr. Tyrrell’s lab began when I first started researching ROP projects. I can still remember scrolling through the various projects, trying to find something that I thought I would be really passionate about. Once I happen upon Dr. Tyrrell’s ROP299, I could feel my heart skip a beat- it was exactly the research project that I was looking for. It explained the use of machine learning in medicine, specifically medical imaging. Being in bioinformatics, this project was exactly what I was looking for; it integrated biology and medicine with computer science and statistics. Once I saw this unique combination, I knew that I needed to apply.
After I applied, I was overjoyed that I had received an interview. When I attended the interview, I was very excited to show Dr. Tyrrell my interest in his research and explain how my past research would help me with this new project. But once I walked into his office, it was unlike any other interview I had ever had; he was able to point out things about myself that I had barely even realized and asked me many questions that I had no answer to. I remember walking out of that interview feeling disappointed as I thought that there was no way I would get a position in his lab, but a few weeks later heard back that I had gotten the position! I was delighted to have the opportunity to prove to Dr. Tyrrell that he made a good choice in choosing me for the position and that I would work hard in his lab and on my project.
The night before my first lab meeting, I researched tons of information on machine learning, making sure to have- what I thought- an in-depth understand of machine learning. But after less than five minutes into the lab meeting, I quickly realized that I was completely wrong. Terms like regression, weights, backpropagation were being thrown around so naturally, and I had absolutely no idea what they were talking about. I walked out of the meeting determined to really begin understanding what machine learning was all about!
Thus began my journey to begin my project. When I decided on my project, it seemed fun and not too difficult- all I have to do is slap on some heat maps to images, right? Well as much as I felt it wouldn’t be too difficult, I was not going to be deceived just as I had before attending our first meeting; and after completion I can definitely say it was not easy! The first problem that I encountered immediately was where to start. Sure, I understood the basic concepts associated with machine learning, but I had no experience or understanding of how to code anything related to creating and using a convolutional neural network. I was fortunate enough to be able to use Ariana’s CNN model. Her model used x-rays of teeth to classify if dental plates were damaged and therefore adding damage (artifacts) to the x-rays of teeth or if the plates were functional. It took me quite some time to understand what each line of code did within the program- the code was incredible, and I could not imagine having to write it from scratch! I then began the code to map the grad-CAM visualizations (resembling heat maps) onto the images that Ariana’s model took as input. I was again fortunate enough to find code online that was similar to what I needed for my project. I made very minor tweaks until the code was functional and worked how I needed it to. Throughout this process of trying to debug my own code or figure out why it wouldn’t even begin running, Mauro was always there to help, always being enthusiastic even when my problem was as silly as accidentally adding an extra period to a word.
Throughout the process, Dr. Tyrrell was always there as well- he always helped me to remember the big picture of what my project was about and what I was trying to accomplish during my time in his lab. This was extremely valuable, as it kept me from accidentally veering off-course and focusing on something that wasn’t important to my project. Without his guidance, I would have never been able to finish and execute the project in the way that I did and am proud of.
Everything that I learned, not only about machine learning, but about how to write a research paper, how to collaborate with others, how to learn from other’s and your own mistakes and how to keep trying new ideas and approaches when it seems like nothing is working, I will always carry with me throughout the rest of my undergraduate experience and the rest of my professional future. Thank you, Dr. Tyrrell, for this experience and every opportunity I was given in your lab.
Dianna McAllister
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Wendi in ROP399: Learning How the Machine Learns…and Improve It!

 

       
Hi everyone! My name is Wendi Qu and I’m finishing my third year in U of T, majoring in Statistics and Molecular Genetics. I did a ROP399 research project with Dr. Pascal Tyrrell from September 2018 – April 2019 and I would love to share it with you!
 
Artificial intelligence, or AI, is a rapidly emerging field becoming ever so popular nowadays, with exponentially increasing research published and companies established. Applications of AI in numerous fields has greatly improved efficacy and convenience, including facial recognition, natural language processing, medical diagnosis, fraud detection, just to name a few. In Dr. Tyrrell’s lab in the Department of Medical Imaging, the gears have been gradually switched from statistics to AI in the past two years for research students. With a Life Science and Statistics background, I’ve always been keen on learning the applications of statistics/data science in various medical fields to benefit both doctors and patients. Having done my ROP299 in Toronto General Hospital, I realized how rewarding it was to use real patient data to study disease epidemiology and how my research can help inform and improve future surgical and clinical practices. Therefore, I was extremely excited when I found out Dr. Tyrrell’s lab and really grateful for this amazing opportunity, where I can go one step further and do AI projects in the field of medical imaging.
 
Specifically, my projects focused on how to mitigate the effect of one of the common problems in machine learning – class imbalance. So, what is machine learning? Simply put, we feed lots of data to a computer, which has algorithms that find patterns in those data and use such patterns to perform different tasks. Classification is one of the common machine learning tasks, where the machine categorizes data to different classes (eg. categorizes an image to “cat” when shown a cat image). A common problem in medical imaging and diagnosis is that there’s way more “normal” data than “abnormal” ones. A machine learning model predicts more accurately when trained on more data, and the shortage of “abnormal” data, which are the most important ones, can impair the model’s performance in practice. Hence, finding methods to address this issue is of great importance. My motivation for doing this project largely comes from how my findings can offer insights on how different methods behave when training sets have different conditions, such as the severity of imbalance and sample size, which can be potentially generalized and help better implement machine learning in practice.
 
However, as with any research project, the journey was rarely smooth and beautiful, especially when I started with almost zero knowledge in machine learning and Python (us undergraduate statisticians only use R…). Starting off by doing a literature search, I realized many methods have been suggested to rectify class imbalance, with two main approaches being re-sampling (i.e. modify the training set) and modifying the cost function of the model. Despite many research done on this topic, I found that such methods were almost never studied systematically to assess their effect on training sets of different natures. The predecessor of this project, Indranil Balki, studied the effect of the class imbalance systematically by varying the class imbalance severity in a training set and see how model performance can be affected. Building on this, I decided to apply different methods to such already established imbalanced datasets and test for model improvement. Because more data lead to better performance, I was also curious if there’s a difference in how much different methods can improve the model in smaller and larger training sets.
 
One of the hardest parts of the project was making sure I was implementing the methods appropriately, and simply writing the code to do exactly what I want it to do. The latter part sounds simple but becomes really tricky when dealing with images in a machine learning context, and is again, even more challenging if you know nothing about Python… ! After digging into more literature, consulting “machine learning people” in the lab (a big shoutout to Mauro, Ahmed, Ariana, and of course, Dr. Tyrrell), I was able to develop a concrete plan, where I implement oversampling methods via image augmentation only when the imbalanced class has fewer images than other classes, and apply under sampling only when imbalanced class has more images; class weights in the cost function will also be adjusted as another method.
 
However, implementing them was a huge challenge. I self-learned Python by taking courses in Python, machine learning, image modification, random forest model, and anything that’s relevant to my project on Datacamp, a really useful website offering courses in different coding languages. Through this process and using Indranil’s code as a skeleton, I was finally able to implement all my methods and output the model’s prediction accuracy! It was a long, painful process which involved constant debugging, but it was never more rewarding to see the code finally run smoothly and beautifully!
 
This wonderful journey has taught me many things – not only have I taken my first step in machine learning, it again reminded me of the most valuable part of doing research, which combines independence, creativity, self-drive, and collaboration. Deciding on a topic, finding a gap, developing your own creative solutions, being motivated to learn new things and conquer challenges, and collaborating with intelligent people surrounding you, are the most invaluable experiences for me this year. Finally, I would love to thank all the amazing people in the lab, especially Mauro, whose machine learning knowledge, coding skills and humour were always there with me, and Dr. Pascal Tyrrell, with more questions back to us when we come with a question, enlightening advice, and a great personality. I appreciate
his amazing experience, and it has inspired me to delve deeper into machine learning and healthcare!
 
Wendi Qu

 

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Rachael Jaffe’s ROP Journey… From the Pool to the Lab!

https://thevarsity.ca/2019/03/10/what-does-a-scientist-look-like/
My name is Rachael Jaffe and I am completing my third year in Global Health, Economics and Statistics. I had no clue what I was getting myself into this year during my ROP (399) with Dr. Tyrrell. I initially applied because the project description had to do with statistics,
and I was inclined to put my minor to the test! Little did I know that I was about to embark on a machine learning adventure.
My adventure started with the initial interview: after a quite a disheartening tale of Dr. Tyrrell telling me that my grades weren’t high enough and me trying to convince him that I would be a good addition to the lab because “I am funny”, I was almost 100% certain that I
wasn’t going to be a part of the lab for 2018-2019 year. If my background in statistics has taught me anything, nothing truly has a 100% probability. And yet, last April I found myself sitting in the department of medical imaging at my first lab meeting.
Fast forward to September of 2018. I was knee deep (well, more accurately, drowning) in machine learning jargon; from learning about the basics of a CNN to segmentation to what a GPU is. From there, I chose a project. Initially, I was just going to explore the relationship between sample size and model accuracy, but then it expanded to include an investigation in k-fold cross validation.
I started my project with the help of Ariana, a student from a lab in Costa Rica. She built a CNN that classifies dentistry PSP’s for damage. I modified it to include a part that allowed the total sample size to be reduced. The relationship between sample size and model accuracy is very well known in the machine learning world, so Dr. Tyrrell decided that I
should add an investigation of k-fold cross validation because the majority of models use this to validate their estimate of model accuracy. With further help from Ariana’s colleague, Mauro, I was able to gather a ton of data so that I could analyze my results statistically.
It was more of a “academic” project as Dr. Tyrrell noted. However, that came with its own trials and tribulations. I was totally unprepared for the amount of statistical interpretation that was required, and it took a little bit of time to wrap my head around the intersection of statistics and machine learning. I am grateful for my statistics minor during this ROP because without it I would’ve definitely been lost. I came in with a knowledge of python so writing and modifying code wasn’t the hardest part.
I learned a lot about the scientific process during my ROP. First, it is incredibly important to pick a project with a clear purpose and objectives. This will help with designing your project and what analyses are needed.  Also, writing the report is most definitely a process. The first draft is going to be the worst, but hang on because it will get better from there. Lastly, I learned to learn from my experience. The most important thing as a budding scientist is to learn from your mistakes so that your next opportunity will be that much better.
I’d like to thank Dr. Tyrrell for giving me this experience and explaining all the stats to me. Also, Ariana and Mauro were invaluable during this experience and I wish them both the best in their future endeavors!

Rachael Jaffe

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Adam Adli’s ROP399 Journey in Machine Learning and Medical Imaging

My name is Adam Adli and I am finishing the third year of my undergraduate studies at the University of Toronto specializing in Computer Science. I’m going to start this blog post by talking a little bit about myself. I am a software engineer, an amateur musician, and beyond all, someone who loves to solve problems and treats every creation as art. I have a rather tangled background; I entered university as a life science student, but I have been a programmer since my pre-teen years. Somewhere along the way, I realized that I would flourish most in my computer science courses and so I switched programs in at the beginning of my third year.
 
While entering this new and uncertain phase in my life and career, I had the opportunity of meeting Dr. Pascal Tyrrell and gaining admission to his research opportunity program (ROP399) course that focused on the application of Machine Learning to Medical Imaging under the Data Science unit of the Department of Medical Imaging.
 
Working in Dr. Tyrrell’s lab was one of the most unique experiences I have had thus far in university, allowing me to bridge both my interest in medicine and computer science in order to gain valuable research experience. When I first began my journey, despite having a strong practical background in software development I had absolutely no previous exposure to machine learning nor high-performance computing.
 
As expected, beginning a research project in a field that you have no experience in is frankly not easy. I spent the first few months of the course trying to learn as much about machine learning algorithms and convolutional neural networks as I could; it was like learning to swim in an ocean. Thankfully, I had the support and guidance of my colleagues in the lab and my professor Dr. Tyrrell throughout the way. With their help, I pushed my boundaries and learned the core concepts of machine learning models and their development with solutions to real-world problems in mind. I finally had a thesis for my research.
 
My research thesis was to experimentally show a relationship that was expected in theory: smaller training sets tend to result in over-fitting of a model and regularization helps prevent over-fitting so regularization should be more beneficial for models trained on smaller training sets in comparison to those trained on larger ones. Through late nights of coding and experimentation, I used many repeated long-running computations on a binary classification model for dental x-ray images in order to show that employing L2 regularization is more beneficial for models training on smaller training samples than models training on larger training samples. This is an important finding as often times in the field of medical imaging, it may be difficult to come across large datasets—either due to the bureaucratic processes or financial costs of developing them.
 
I managed to show that in real-world applications, there is an important trade-off between two resources: computation time and training data. L2 regularization requires hyperparameter tuning which may require repeated model training which may often be very computationally expensive—especially in complex convolutional neural networks trained on large amounts of data. So, due to the diminishing returns of regularization and the increased computational
costs of its employment, I showed that L2 regularization is a feasible procedure to help prevent over-fitting and improve testing accuracy when developing a machine learning model with limited training data.
 
Due to the long-running nature of the experiment, I tackled my research project as not only a machine learning project but also a high-performance computing project as well. I so happened to be taking some systems courses like CSC367: Parallel Programming and CSC369: Operating Systems at the same time as my ROP399, which allowed me to better appreciate the underlying technical considerations in the development of my experimental
machine learning model. I harnessed powerful technologies like Intel AVX2 vectorization instruction set for things like image pre-processing on the CPU and the Nvidia CUDA runtime environment through PyTorch to accelerate tensor operations using multiple GPUs. Overall, the final run of my experiment took about 25 hours to run even with all the high-level optimizations I considered—even on an insane lab machine with an Intel i7-8700 CPU and an Nvidia GeForce GTX Titan X!
 
Overall, my ROP not only opened a door to the world of machine learning and high-performance computing for me but in doing so, it taught me so much more. It strengthened my independent learning, project management, and software development skills. It taught me more about myself. I feel that I never experienced so much growth as an academic, problem-solver, and software engineer in such a condensed period of time.
 
I am proud of all the skills I’ve gained in Dr. Tyrrell’s lab and I am extremely thankful for having received the privilege of working in his lab. He is one of the most supportive professors I have had the pleasure of meeting.
 
Now that I have completed my third year of school, I’m off to begin my year-long software engineering internship at Intel and continue my journey.
 
Signing out,

Adam
Adli

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Step 1 in ROP399 – What’s my project?

This week I finally decided on my project topic!

During last week’s lab meeting, Dr. Tyrrell brought up some potential topics for us to choose from. This included determining the appropriate sample size for machine learning, class imbalance problem, participating in the dental project and the ultrasound project that has just been brought up.

After the lab meeting, I talked to Wenda and Ariana regarding the dental project that they have been working on. This was the project that I wanted to be in the most primarily because I intend to go to dental school after graduation, and being involved in a dental project would offer more exposure to this field. However, after the brief introduction and update on the current progress by Wenda and Ariana, I realized that there might not be much to do as a complete project. Hanatu, an independent research student, would also be working on this project, leaving fewer gaps that need to be addressed for the project. Because my expectation is to work on a project independently on a topic where there’s plenty of freedom, I decided to change gears and look at other ideas.

The class imbalance topic was the next thing that caught my interest. Indranil, who happened to be my mentor before I joined the lab, has been working on the class imbalance project before. I immediately contacted him regarding this project and got his project report. I was told that this topic is more technical and less clinical than the dental project, so I didn’t know if I would like the topic. Surprisingly, I found it really interesting and has great implications. Indranil studied the effect of class imbalance using images in the IRMA database and applied the random forest model. By manually changing the sample size of one class, he found that as the proportion of the imbalanced set goes up, the overall accuracy of the model decreases, while the accuracy for the imbalanced class increases. I found it interesting and useful, as class imbalance can be very common in any dataset, especially in medical imaging. Studying its effect can help identify this issue when machine learning is applied to assist with medical imaging.

I then met with Indranil on the possible projects on this topic, and the most natural one would just be investigating which method can better mitigate the class imbalance problem – as a continuation after studying its effects. Next, I researched on any existing literature on this topic specifically in medical imaging, and very little was found. The most commonly used methods for class imbalance include over-sampling, under-sampling, and changing the weight for the imbalanced class coefficient in the cost function. I met with Dr. Tyrrell, he liked the idea for my project, and suggested that I focus on these 3 main methods (mentioned above).

I am excited about my project (and most importantly, really interested). I decide to ask for the code that Indranil used to do the image preprocessing and creating imbalanced classes as a starting point. For my next steps, I’m also planning to learn more about the different methods in addressing this problem as well as how to code in Python.

Looking forward to working on my project!

Wendi
Sep.28, 2018

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Summer 2018 ROP: Wenda’s in the house!

Hello everyone, my name is Wenda Zhao. I’m starting my fourth year in September majoring in neuroscience and pathobiology. I did a research opportunity project (ROP) 399 course with Dr. Tyrrell this summer. And I’m here to share some of my experiences with you.
Today is a hot and humid Friday in southeast China, where I’m back home from school for the rare luxury of a short break before everything gets busy again. Summer is coming to an end, so is my time with Dr. Tyrrell and his incredible team, some of whom I have got to know, spent most of the summer working with and befriend. I have just handed in my report for the project I did over the past three months on the segmentation, characterization and superimposition of dental
X-ray artifacts. And now, looking back, it was one of the best learning experiences I have ever had, through an enormous amount of self-teaching, practicing, troubleshooting, discussing and debating. As with all learning experiences, the process can be long and bewildering, sometimes even tedious; yet rewarding in the end.
 
It all began on a cold April morning, with me sitting nervously in Dr. Tyrrell’s
office, waiting for him to print out my ROP application and start off the interview. At that point, I just ended my one-year research at a plant lab and was clueless of what I was going to do for the following summer. Coming from a life science background, I went into this interview for a machine learning project in medical imaging knowing that I wasn’t the most competitive candidate nor the most suitable person to do the job. Although I tried presenting myself as someone who had had some experience dealing with statistics by showing Dr. Tyrrell some clumsy work I did for my previous lab, the flaws were immediately noticed by him. I then found myself facing a series of questions which I had no answers to and the interview quickly turned into what I thought to be a disaster for me. I was therefore very shocked when I received an email a week later from Dr. Tyrrell informing me that I had been accepted. I happily went onboard, but joys aside, part of me also had this big uncertainty and doubt that later followed me even to my first few weeks at the lab.
 
At the beginning, everything was new. I started off learning the software KNIME, an open-source data analytics platform that is capable of doing myriads of machine learning tasks. I had my first taste doing a classification problem, where we trained a decision tree model to identify a given X-ray to either be of a hand or a chest. It was a good introductory task to illustrate all the basic concepts in machine learning such as “training set”, “test set”, “input” and “output/label”. We ended up obtaining an accuracy of around 90% on the test set. That was the first time I witnessed the power of machine learning and I was totally amazed by it. I spent the next week or so watching more videos on the topic including state of the art algorithms such as convolutional neural network (CNN). While absorbing knowledge everyday was fun, I was at the same time a little lost about the future of my project. I began to realize that this experience is going to be very different from my past ones in wet labs, where a lot of the times you were already told what to do and all you need is to conduct the experiments and get the results. Here the amount of freedom that I have on my schedule, task and even the project itself was refreshing but at the same time terrifying. On retrospect, I considered myself lucky for that it was around that time of lost when the Faculty of Dentistry proposed a collaboration with us, which ended up being my project for the summer.
 
The dentistry project, as we so called, concerns a type of dental X-ray sensor called Phosphor Storage Plates (PSPs) which are very commonly used because of its easy placement in the oral cavity and the resulting minimum discomfort. The sensors, however, can accumulate damages over time, which would show up in the final image as artifacts with various appearances. Such artifacts could get in the way of diagnosis; thus, the plates need to be discarded before it’s too damaged. But how damaged is too damaged? For the moment, nobody has answers to that. Our goal is to use machine learning to learn the relationship between artifacts and whether they would affect diagnosis. Eventually, we can use that model to make predictions for a given plate and offer dentists advice as in when to discard it. The entire project is huge and the part we played in this summer mainly contributes as preparatory work. We segmented the artifacts from the image and clustered them into five groups based on 9 hand-engineered features. This characterization of the single artifacts can serve as the input for the model. We also created a library of superimposed images of artifact masks and real teeth backgrounds to mimic images taken with damaged sensors in real clinical settings. We did this so that dentists can take a look at these images and give a diagnosis. Comparing that with the true diagnosis, we can obtain the labels for whether a given artifact will affect diagnosis or not. And this will be the output of the model. The testing of these images is currently underway, and the results will be available in early September for further analysis.
 
With the project established and concrete goals ahead, the feeling of uncertainty
gradually went away. But it was never going to be easy. There were times when
we hit the bottleneck; when our attempts have failed miserably; when we had to give up on a brilliant idea because it didn’t go our ways. But after stumbling through all the challenges and pitfalls, we found ourselves new. I was a bit lost at the beginning of this summer. But over the summer I learned a lot about the very cool and growingly crucial field of machine learning; I grew a newfound appreciation for statistics and methodology; I picked up the programming language python, which I had been wanting to do for years and, most importantly, I did more thinking than I ever would if I were to just follow instructions blindly. And in the end, I believe that science is all about thinking. So for you guys out there reading the blog, if you’re coming to this lab from a totally different background and not entirely sure about the future, don’t be afraid. And I hope you find what you come here looking for, just like I did.
 
Finally, I want to thank the people who’s helped me along the way and who’s made the lab such an enjoyable place: Hershel, Henry, Rashmi, John and Trevor; and last but not least, Dr. Tyrrell, without whose kindly offer and guidance I would never have had such an amazing experience. Here’s to an unforgettable summer and a strong start of the new school year. Cheers!
 
Wenda Zhao
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ROP299 2017-2018: A Medical Imaging Journey from a Humanities Perspective

My name is Samantha Santoro, and I am completing my second year in the English and Biology majors at the University of Toronto, St. George. A rather unconventional combination, when reviewing past students of Dr. Tyrrell’s lab. I was a 2017-2018 Research Opportunity Program (ROP) student in Dr. Pascal Tyrrell’s lab, and my work chiefly consisted of evaluating the internal vessel wall volumes of carotid arteries in a particular cohort of patients provided by the ongoing prospective CAIN study. My ROP was in the field of Medical Imaging. I am the co-president of the student club known as Watsi, with the main chapter based in San Francisco. I am also a special contributor to the Rare Disease Review, along with volunteering at an amalgamation of charity walks and fundraisers.

My ROP project was a turbulent experience – although that word is typically associated with a negative connotation, I regard my ROP299Y1 as one of the most humbling, interesting, and educative experiences that I have had thus far – most definitely not negative. However, to say everything went smoothly would be discrediting the lessons I learned from when things were not idyllic and smooth. My project, as aforementioned, statistically analyzed data provided by patients part of the CAIN study (an analysis that could not have existed without Dr. Tyrrell’s generous and unwavering support). My study determined that patients who were found to have IPH, or what is known as intraplaque hemorrhage, when I analyzed their MRIs, were also found to have increased vessel wall volume. This conclusion is incredibly significant, as IPH is a surrogate marker for atherosclerosis and could potentially be an indicator for patients at risk of future cerebrovascular events (namely, ischemic stroke). As strokes are currently the number three killer in the U.S and Canada alone, and heart disease number one, having a potential indicator for patients at risk of stroke would greatly benefit clinicians in their practice, as well as patients themselves.

As aforementioned, studies similar to my own are currently underway by the Canadian Atherosclerosis Imaging Network, furthering the important research in this field. The VBIRG (Vascular Biology Imaging Research Group) was the lab in which I primarily worked throughout the course of my ROP, at Sunnybrook Hospital. Moreover, I also worked on systematic reviews and reports outside of the focus of my project, in the fields of medical ethics and AI in the radiology workplace – both of which were opportunities provided to me by Dr. Tyrrell, and both of which were incredibly valuable experiences, allowing for me to broaden my knowledge of certain areas of medicine and science that are developing and expanding.

Although my project was littered with its own respective difficulties – a substantial number of drafts throughout each step of the program (more than I had ever made, even being an English student); a reluctant, but later fulfilling, acquaintanceship with the post-processing software VesselMass; and several late nights learning about the field of statistics – it is in light of these difficulties, and at present having overcome them throughout my ROP, that I remember Dr. Paul Kalanithi’s words in his memoir When Breath Becomes Air: “It occurred to me that my relationship with statistics changed as soon as I became one”. He, too, had studied Biology and English. I may not have played a lead role in the statistics I had been working with, but I can now say that understanding what they meant and how they were formulated has generated a deep respect in me for the field of statistics.

My poster was on display at the 2018 Research Opportunity Undergraduate Fair. Special thanks to Mariam Afshin, my supervisor at Sunnybrook Hospital; Bowen Zhang, for answering each question I had while at Sunnybrook; John, and the rest of the lab team; and Dr. Pascal Tyrrell, for answering my email last February and holding my interview on the same day as my Chemistry exam. Never before had I met such an – in a word – outstanding professor, and I dare say that I will never meet one like him throughout the rest of my academic journey.

Samantha Santoro

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A Medical Ethics ROP Journey with Jayun Bae

Jayun Bae – ROP299Y 2016-17
My name is Jayun Bae and I am completing my second year in the Neuroscience and Bioethics majors at the University of Toronto, St. George. I was a 2016-2017 Research Opportunity Program (ROP) student in Dr. Pascal Tyrrell’s lab, working on a study that investigated the ethics of sharing patient data with private organizations (see my timeline above). I am a member of the Hart House Debating Club and an events associate for the Life Science Student Network. 
                                                               
My ROP project was necessitated by the partnership proposed by the Medical image Networking Enterprise (MiNE) that would establish a data-sharing relationship between public and private sector organizations. The ethical concerns with the partnership involved patient consent, privacy, and financial gain – but there were also issues that I
uncovered throughout the project. It quickly became clear that the answers could not be found through an examination of precedence or legal documents, because many of the research actions that would take place (specifically involving private organizations) fell in the grey area between what was legal and what was ethical. For example, the Personal Information Protection and Electronic Documents Act (PIPEDA) and Personal Health Information Protection Act (PHIPA) are two guidelines for organizations to follow when handling patient data – but neither are able to clearly and positively dictate how this partnership should operate.
Therefore, I developed a study that would seek expert opinions through the administration of a survey. I conducted interviews at Sunnybrook Health Sciences Centre and the University of Toronto and performed qualitative data analysis. My ROP project was presented at the ROP Poster Fair and the Victoria College Research Day events. The ROP was an extremely valuable experience in gaining research skills, and I’m grateful to
Dr. Tyrrell for the guidance and mentorship. The project is not yet completed, so I am looking forward to continuing the study beyond the scope of the ROP.   Please have a look at my poster from the 2017 ROP Research Day below: